Type V,HMSN

《英文msh詞典》Type V,HMSN
[入口詞] Type V,HMSN
[主題詞] Spastic Paraplegia,Hereditary
[英文釋義] A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive,autosomal dominant,and x-linked forms of hereditary spastic paraplegia have been identified. Clinically,patients present with slowly progessive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)